Simmonds Disease- Primary pituitary insufficiency, in which the secretion of the majority of the hypophysial hormones is reduced, with secondary hypofunction of the peripheral endocrine glands.
The clinical picture depends on the degree of reduction of the pituitary function.
- Sharp weight loss - the dominant symptom of the disease
- Symptoms of thyroid insufficiency, gonads, adrenal cortex.
The diagnosis is based on anamnestic data, the clinic, a decrease in the content of 17-oxycorticosteroids in the blood and daily urine, low concentrations of TSH, T3, T4 in plasma. X-ray examination of the spine- not often occurrences of osteoporosis.
- Diet with the introduction of a sufficient amount of proteins, fats, vitamins.
- Hormone replacement therapy
- Somatotropin to stimulate the growth of babies
- Glucocorticoids. In domestic practice, prednisone is often used at 5-10 mg / day with an increase in dose during stress. With a decrease in blood pressure, low sodium content and a high content of potassium in the serum, on the background of taking prednisolone, mineralocorticoids are additionally prescribed (for example, deoxycorticosterone acetate 5 mg 2-3 r / week parenteral or 5-15 mg / day 1-3 r / day under the tongue)
- Sex hormones: the estrogen-progesterone combination helps to normalize menstrual function, and testosterone is prescribed to men to restore libido and potency
Thyroidinhormones, for example levothyroxine
- Anabolic steroid.